SP-0008: Dose escalation using altered fractionation

Using SAS to Assess Dose Proportionality in Dose Escalation Studies

Dose escalation studies provide a good opportunity to assess the linearity of PK parameters. This paper describes hypothesis testing and confidence interval (C.I.) methods for assessing dose proportionality based on linear regression and weighted least squares (WLS) linear regression. SAS® code is presented using an example study and AUCinf data.

Radiotherapy Dose-Fractionation

Individualized Tamoxifen Dose Escalation-Letter.

In a recent commentary (1), Hertz and Rae have put the relevance of pharmacokinetically guided dosing of tamoxifen into perspective. We appreciate this effort and fully agree that more evidence is required to refine the relationship between exposure to the active tamoxifen metabolite endoxifen and clinical outcome parameters. On the basis of the relatively long survival of adjuvantly treated br...

Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy

Radiotherapy is crucial and substantially contributes to multimodal cancer treatment. The combination of conventional fractionation radiotherapy (CFRT) and systemic therapy has been established as the standard treatment for many cancer types. With advances in linear accelerators and image-guided techniques, high-dose fractionation radiotherapy (HFRT) is increasingly introduced in cancer centers...

Dose escalation using conformal high-dose-rate brachytherapy improves outcome in unfavorable prostate cancer.

PURPOSE To overcome radioresistance for patients with unfavorable prostate cancer, a prospective trial of pelvic external beam irradiation (EBRT) interdigitated with dose-escalating conformal high-dose-rate (HDR) prostate brachytherapy was performed. METHODS AND MATERIALS Between November 1991 and August 2000, 207 patients were treated with 46 Gy pelvic EBRT and increasing HDR brachytherapy b...